Terrorists kidnap the Russian Prime Minister’s 2 kids, take Chernobyl nuclear power plant and threaten to blow up a reactor. 4 Universal Soldiers go in but are no match to a Next Gen. UniSol Luc (Jean-Claude Van Damme) goes in but faces 2 NGUs.

John looks to take down Luc Deveraux after a home invasion claims his wife and daughter. The fight pits John against Andrew Scott and an army of genetically enhanced warriors; meanwhile, he must contend with a UniSol in relentless pursuit.